The CPK total serum test is typically ordered by a healthcare provider when there is suspicion of muscle injury, heart attack, or muscular disorders. It may be recommended for individuals experiencing symptoms such as muscle pain, weakness, or fatigue, as well as those with risk factors for heart disease or muscle disorders. Additionally, athletes or individuals engaging in strenuous physical activity may undergo CPK testing to monitor muscle health. Ultimately, the decision to perform the test is based on the individual's medical history, symptoms, and the judgment of the healthcare provider.